Human Genome Infomatics
- Post Sequence Genomics -




List of Publications(with review)

  1. N. Iizuka, M. Oka, H. Yamada-Okabe, N. Mori, T. Tamesa, T. Okada, N. Takemoto, A. Tangoku, K. Hamada, H. Nakayama, T. Miyamoto, S. Uchimura and Y. Hamamoto: ``Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method'', Cancer Research, 62, pp.3939-3944 (2002).

  2. N. Iizuka, M. Oka, H. Yamada-Okabe, N. Mori, T. Tamesa, T. Okada, N. Takemoto, K. Hashimoto, A. Tangoku, K. Hamada, H. Nakayama, T. Miyamoto, S. Uchimura, and Y. Hamamoto, ``Differential gene expression in distinct virologic types of hepatocellular carcinoma: Association with liver cirrhosis'', Oncogene, 22, pp.3007-3014 (2003).

  3. N. Iizuka, M. Oka, H. Yamada-Okabe, M. Nishida, Y. Maeda, N. Mori, T. Takao, T. Tamesa, A. Tangoku, H. Tabuchi, K. Hamada, H. Nakayama, H. Ishitsuka, T. Miyamoto, A. Hirabayashi, S. Uchimura, and Y. Hamamoto: ``Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection'', Lancet, 361, pp.923-929 (2003).

  4. S. Uchimura, N. Iizuka, M. Oka, and Y. Hamamoto: ``Evaluation of Fast Nearest-Neighbor Algorithms for Microarray Data Analysis'', Proc. of 5th Int. Workshop on Advanced Genomics, Pacifico Yokohama, Japan, pp.84, (June. 2003).

  5. T. Miyamoto, Y. Muto, N. Iizuka, M. Oka, and Y. Hamamoto: ``Comparison of nonparametric classifiers with microarray expression data'', Proc. of 5th Int. Workshop on Advanced Genomics, Pacifico Yokohama, Japan, pp.85, (June. 2003).

  6. T. Miyamoto, S. Uchimura, Y. Hamamoto, N. Iizuka, M. Oka, H. Yamada-Okabe, "Comparative study of feature selection methods on microarray data" IEEE EMBS Asian-Pacific Conf. Biomedical Engineering 2003, Keihanna, (Oct. 2003).

  7. N. Iizuka, M. Oka, K. Yamamoto, A. Tangoku, K. Miyamoto, T. Miyamoto, S. Uchimura, Y. Hamamoto, and K. Okita, ``Identification of common or distinct genes related to antitumor activities of a medicinal herb and its major component by oligonucleotide microarray'', International Journal of Cancer, 107(4), pp.666-672 (2003).

  8. T. Okada, N. Iizuka, H. Yamada-Okabe, N. Mori, T. Tamesa, N. Takemoto, A. Tangoku, K. Hamada, H. Nakayama, T. Miyamoto, S. Uchimura, Y. Hamamoto, and M. Oka, ``Gene expression profile linked to p53 status in hepatitis C virus-related hepatocellular carcinoma'', FEBS Letters, 555(3) pp.583-590 (2003).

  9. N. Iizuka, M. Oka, H. Yamada-Okabe, K. Hamada, H. Nakayama, N. Mori, T. Tamesa, T. Okada, N. Takemoto, K. Matoba, M. Takashima, K. Sakamoto, A. Tangoku, T. Miyamoto, S. Uchimura, and Y. Hamamoto, ``Molecular signature in three types of hepatocellular carcinoma with different viral origin by oligonucleotide microarray'', International Journal of Oncology, 24, pp.565-574 (2004).

  10. T. Miyamoto, S. Uchimura, N. Iizuka, M. Oka, H. Yamada-Okabe, and Y. Hamamoto, ``Evaluation of scoring systems with microarray data for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection'', American Association for Cancer Research 95th Annual Meeting, March 27-31 2004, Orange Country Convention Center Orland, Florida (2004).

  11. N. Iizuka, H. Yamada-Okabe, T. Tamesa, T. Okada, N. Takemoto, T. Miyamoto, S. Uchimura, Y. Hamamoto, and M. Oka ``Molecular profiling based on p53 abnormality in hepatitis C virus-associated hepatocellular carcinoma by a supervised learning method'', American Association for Cancer Research 95th Annual Meeting, March 27-31, 2004, Orange Country Convention Center Orland, Florida (2004).

  12. T. Miyamoto, S. Uchimura, Y. Hamamoto, N. Iizuka and M. Oka, ``Comparison of microarray-based predictive systems for early recurrence of cancer'', Proc. 17th International Conference on Pattern Recognition, Cambridge, UK, Vol.2, pp.347-350 (Aug.2004).

  13. Norio Iizuka, Masaaki Oka, Yoshihiko Hamamoto, Naohide Mori, Takao Tamesa, Akira Tangoku, Takanobu Miyamoto, Shunji Uchimura, Hironobu Nakayama, Kenji Hamada and Hisafumi Yamada-Okabe, ``Altered Levels of Cytochrome P450 Genes in Hepatitis B or C Virus-infected Liver Identified by Oligonucleotide Microarray'', Cancer Genomics & Proteomics 1, pp.53-58 (2004).

  14. Norio Iizuka, Masaaki Oka, Takao Tamesa, Yoshihiko Hamamoto and Hisafumi Yamada-Okabe, ``Imbalance in Expression Levels of Insulin-like Growth Factor 2 and H19 Transcripts Linked to Progression of Hepatocellular Carcinoma'', Anticancer research 24, pp.4085-4090 (2004).

  15. Kaoru Omori, Shuji Terai, Tsuyoshi Ishikawa, Kouji Aoyama, Isao Sakaida, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, and Kiwamu Okita ``Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression'', FEBS Letters, 578, pp.10-20 (2004).

  16. N. Iizuka, Y. Hamamoto, and M. Oka, ``Predicting individual outcomes in hepatocellular carcinoma'', Lancet, 364, pp.1837-1839 (2004).

  17. Norio Iizuka, Masaaki Oka, Hisafumi Yamada-Okabe, Naohide Mori, Takao Tamesa, Toshimasa Okada, Norikazu Takemoto, Kazuhiko Sakamoto, Kenji Hamada, Hideo Ishitsuka, Takanobu Miyamoto, Shunji Uchimura, Yoshihiko Hamamoto, ``Self-organizing-map-based molecular signature representing the development of hepatocellular carcinoma'', FEBS Letters, 579, pp.1089-1100 (2005).

  18. Katsuhiro Matoba, Norio Iizuka, Toshikazu Gondo, Tokuhiro Ishihara, Hisafumi Yamdada-Okabe, Takao Tamesa, Norikazu Takemoto, Kiichiro Hashimoto, Kazuhiko Sakamoto, Takanobu Miyamoto, Shunji Uchimura, Yoshihiko Hamamoto and Masaaki Oka, ``Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocelluar carcinoma'', International Journal of Cancer, 115, pp.231-240 (2005).

  19. N. Iizuka, Y. Hamamoto and M. Oka, ``Prediction of cancer outcome with microarrays'', Lancet, 365, pp.1683-1684 (2005).

  20. A. Hara, N. Iizuka, Y. Hamamoto, S. Uchimura, T. Miyamoto, R. Tsunedomi, K. Miyamoto, S. Hazama, K. Okita and M. Oka, ``Molecular dissection of a medicinal herb with anti-tumor activity by oligonucleotide microarray'', LIFE SCIENCE, Vol. 77, No. 9, pp.991-1002 (2005).

  21. R. Tsunedomi, N. Iizuka, Y. Hamamoto, S. Uchimura, T. Miyamoto, T. Tamesa, T. Okada, N. Takemoto, M. Takashima, K. Sakamoto, K. Hamada, H. Yamada-Okabe, and M. Oka, ``Patterns of expression of cytochrome P450 genes in progression of hepatitis C virus-associated hepatocellular carcinoma'', International Journal of Oncology, Vol. 27, pp.661-667 (2005).

  22. Norikazu Takemoto, Norio Iizuka, Hisafumi Yamada-Okabe, Kenji Hamada, Takao Tamesa, Toshimasa Okada, Kiichiro Hashimoto, Kazuhiko Sakamoto, Motonari Takashima, Takanobu Miyamoto, Shunji Uchimura, Yoshihiko Hamamoto and Masaaki Oka, ``Sex-based molecular profiling of hepatitis C virus-related hepatocellular carcinoma'', International Journal of Oncology, Vol.26, pp.673-678 (2005).

  23. Kiwamu Okita, Isao Sakaida, Shuji Terai, Naoki Yamamoto, Kaoru Omori, Tsuyoshi Ishikawa, Kouji Aoyama, Koh Shinoda and Yoshihiko Hamamoto, ``Development of New Therapy in Fulminant Hepatitis from Glucagon-Insulin Therapy to Bone Marrow Cell Transplantation'', THE BULLETIN OF THE YAMAGUCHI MEDICAL SCHOOL, 52(3-4), pp.25-31 (2005).

  24. Tomomitu Sato, Norio Iizuka, Yoshihiko Hamamoto, Shigefumi Yoshino, Toshihiro Abe, Shigeru Takeda, Shunji Uchimura, Takanobu Miyamoto, Fumiyoshi Sei, Kenji Hamada, Hisafumi Yamada-Okabe and Masaaki Oka, ``Esophageal squamous cell carcinomas with distinct invasive depth show different gene expression profiles associated with lymph node metastasis'', International Journal of Oncology, Vol.28, pp.1043-1055 (2006).

  25. Ishikawa, T., Terai, S., Urata, Y., Marumoto, Y., Aoyama, K., Sakaida, I., Murata, T., Nishina, H., Shinoda, K., Uchimura, S., Hamamoto, Y.,Okita, K., ``Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes'', Cell and Tissue Research, 323 (2), pp.221-231 (2006).

  26. Shunji Uchimura, Norio Iizuka, Takao Tamesa, Takanobu Miyamoto, Yoshihiko Hamamoto and Masaaki Oka, ``Resampling Based on Geographic Patterns of Hepatitis Virus Infection Reveals a Common Gene Signature for Early Intrahepatic Recurrence of Hepatocellular Carcinoma'', ANTICANCER RESEARCH, Vol.27, pp.3323-3330 (2007).

  27. Hideaki Somura, Norio Iizuka, Takao Mamesa, Kazuhiko Sakamoto, Takashi Hamaguchi, Ryouichi Tsunedomi, Hisafumi Yamada-Okabe, Mikiko Sawamura, Masaya Eramoto, Takanobu Miyamoto, Yoshihiko Hamamoto and Masaaki Oka, ``A Three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy'', ONCOLOGY REPORTS, Vol.19, pp.489-495 (2008).


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